Correlations Between Clinical and Metabolic Variables and Smoking among Antipsychotic- Naïve First-Episode and Nonadherent Chronic Patients with Psychosis

An interaction between smoking and antipsychotic medications could potentially affect treatment efficacy promote metabolic side effects. We investigated the contribution of status towards Positive Negative Syndrome Scale (PANSS) scores syndrome- related parameters (plasma lipid glucose concentrations, body mass index) among two groups unmedicated patients with psychosis from Croatian population: antipsychotic-naïve first-episode nonadherent chronic patients. Previous data are inconsistent regarding effects on clinical psychopathology or minimally medicated psychosis, no studies have examined potential influence psychosis. Information about nonadherence was obtained via auto-anamnestic hetero-anamnestic information. PANSS were while in a psychotic state during illness requiring hospitalization. Plasma total cholesterol, LDL HDL cholesterol (HDL- c), triglyceride, levels determined after 12-hour fasting period. Compared non-smoking individuals, smokers exhibited significantly lower depression factor scores, higher triglyceride triglyceride/HDL- c ratio (p < 0.05). negative symptoms HDL- levels. Contributions to ranged ~ 3.4 % 10 %. Our present results indicated that may be associated less severe psychopathology, increased risk for abnormalities,